Cryptococcus neoformans is an encapsulated yeast in the natural environment, and soils often contaminated with bird droppings are the most important source of contamination. In this article, a 61-year-old female recipient of renal transplantation, who was diagnosed with disseminated cryptococcal infection with skin involvement, is presented. Physical examination of the patient was found to have atypical lesions on her face. At the end of the 72-hour incubation of the scraping sampling from the patient’s lesion; Crytococcosis was diagnosed by detecting encapsulated yeast fungi in staining with Indian ink. Yeast structures compatible with C.neoformans were seen. L-Amphotericin B treatment, which was started. The patient died on the 8thday of follow-up despite extensive and effective antifungal therapy. In conclusion, it should be considered that opportunistic fungal infections that may develop due to the use of immunosuppressive agents in patients undergoing solid organ transplantation